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81% women, average age 56, and BMI of 40

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As with obesity, reduced muscle strength in sarcopenia is associated with disability and poor QoL [25], as well as risk of adverse events and subsequent hospital care, increasing the financial burden to the health service [41]

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Most of the CDDO-ME subjects also exhibited fluid retention with an increase in blood pressure, heart rate, and serum brain natriuretic peptide (BNP) in addition to a decrease in blood concentrations of albumin and hemoglobin compared to the placebo subjects