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Clinical Presentations: Available in tablets (dragees) for maintenance or injectable solutions for acute cases (according to medical evaluation)

Slower titration may be necessary

Intranasal delivery, though less studied with Dihexa, would theoretically provide direct CNS access with minimal systemic exposure, potentially requiring the least frequent administration to maintain effective brain tissue concentrations

A lack of vascularization could potentially be overcome by the use of a 3D-print chip that combines hPSC-derived kidney organoids co-cultured with glomerular microvascular endothelial cells (GMECs) in a gelatin-fibrin ECM, as recently reported (Homan et al

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