Zitman-Gal et al
The risk of hypoglycemia with GLP-1 RAs is low when used as monotherapy
Fundamental Body Composition Principles Provide Context for Fat-Free and Skeletal Muscle Loss With GLP-1 RA Treatments, Journal of the Endocrine Society, Volume 8, Issue 11, November 2024, bvae164, 7
GLP-1 Drugs Like Ozempic Carry Elevated Risks of Muscle Loss and Malnutrition in Adults Over 65 The weight-loss drugs that have transformed obesity medicine for millions of Americans carry specific safety risks in adults over 65 that differ significantly from those in younger patients, and those risks are not routinely addressed in the prescribing frameworks developed before older adults were widely eligible for coverage
The company notes that maintaining healthy diet and activity patterns helps sustain any improvements
The timing of fatigue onset relative to medication initiation provides important diagnostic information, though coincidental conditions may emerge during treatment