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In a process quite similar to human placental development, trophoblast cells of the labyrinth layer adjacent to the fetal endothelium fuse with each other, forming multinucleated syncytiotrophoblast cells (STB)

57 This understanding enables the use of exosomes from blood samples as a minimally invasive method to assess the CNSs condition and metabolic processes during pathological states, such as COVID-19 and PACS

This occurs through multiple mechanisms

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Karlik M, Valkovic P, Hancinova V, Krizova L, Tothova L, Celec P