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[PubMed] [Google Scholar] Heppner KM, Baquero AF, Bennett CM, Lindsley SR, Kirigiti MA, Bennett B, Bosch MA, Mercer AJ, Rnnekleiv OK, True C, 2017

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it is known that this signaling pathway is closely associated with articular cartilage surface destruction during the occurrence and development of RA, which may be related to its regulation of chondrocyte ferroptosis and promotion of inflammatory factor expression, as supported by RNA sequencing, molecular biology experiments, and both in vivo/in vitro experiments