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The fatigue during early semaglutide use more likely results from caloric restriction, changes in eating patterns, and the medication adjusting appetite and satiety signals
In the brain, GLP-1 receptor activation affects areas that regulate appetite and satiety, leading to reduced hunger and increased feelings of fullness
However, a national Blue Health Intelligence study from the Blue Cross Blue Shield Association finds that more than 30% of patients dropped out of treatment after the first four weeks and 58% of patients taking the medications for weight loss discontinued use before seeing a clinical benefit
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Patients should avoid sudden increases in refined carbohydrates and ultra-processed foods, which can amplify hunger signals during the adjustment window
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