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128 Since mutant p53 changes immune cell infiltration and phenotypes, we can overexpress TBK1 to reactivate IRF3, which disrupts mutant p53 binding to TBK1 and activates the immune system to suppress tumor growth

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demonstrated reduced expression of mitochondrial proteins in early-stage lipedema using proteomic profiling, though they did not identify upstream regulatory nodes or link the observed changes to DNA methylation [22]

2019;181(6):R211-R234

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