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Fatigue and Cognitive Impairment First-generation antihistamines (like diphenhydramine/Benadryl and hydroxyzine) are notorious for causing drowsiness because they cross the blood-brain barrier and block H1 receptors in the central nervous system

t = 1.16, p = 0.25)

3 Mohn, E.S., Kern, H.J., Saltzman, E., Mitmesser, S.H., McKay, D.L