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Using any IV substance outside a controlled setting is extremely dangerous

This pain, characterized by originating from regions with abnormal sensation, may present as pain in the absence of stimuli, pain from normally nonpainful stimuli (allodynia), or disproportionate pain in response to harmful stimuli (hyperalgesia)

Hauge-Evans, A

She was 225 pounds at the time

2019;67(Supplement):S3844

In general, dose selection for an elderly patient should be cautious, usually starting at the low end of the dosing range, reflecting the greater frequency of decreased hepatic, renal, or cardiac function, and of concomitant disease or drug therapy