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Treatment of idiopathic guttate hypomelanosis with liquid nitrogen: light and electron microscopic studies

Mion F, Napolon B, Roman S, Malvoisin E, Trepo F, Pujol B, et al

The hypothesis may be correct

IcoSema doses were adjusted in ten dose-step increments or decrements once weekly following a treat-to-target approach based on three pre-breakfast self-measured blood glucose (SMBG) values, measured on the 2 days before titration and on the day of titration (target SMBG: 4.47.2 mmol/l) (ESM Table 3)

IV infusion (250-500 mg over 2-4 hours) delivers the highest peak levels and is used in clinical settings