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How Does Melanotan 2 Work

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Current Topics in Medicinal Chemistry, 7 (11), 1098-1106

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However, it reduced forward locomotion ( Fig 7A ), suggesting it slightly affected the overall motor map profile relative to control rats that received saline (see Fig 7E , see blue dots slightly separated from control black dots)

This pathway involves activation of phosphatidylinositol phospholipase C (PI-PLC), phosphatidylinositol 4,5-bisphosphate (PIP 2 ) and inositol trisphosphate (IP 3 ), ultimately resulting in mobilization of intracellular Ca 2+ stores (Camia et al., 2007)