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Individuals with a history of pulmonary, neurologic, hepatic, rheumatic, hematologic, or renal chronic disease, who were treated with immunosuppressive therapy in the 6 months prior to screening, or who used medication or supplements that may have confounded the study results were also excluded

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A medicine supply notification issued by the Department of Health and Social Care on 27 June 2023 said the high impact shortage has been caused by an increase in demand for these products for licensed and off-label indications, with supply not expected to return to normal until at least mid-2024