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doi:10.1016/j.mehy.2012.07.034, PMID: 22951418 Marshall HE, Stamler JS (2001) Inhibition of NF-kappa B by S -nitrosylation

doi:10.1146/annurev.med.60.041807.123308 [16] Varga EA, Sturm AC, Misita CP, Moll S

Common symptoms include persistent or unusual fatigue, mood swings, excessive irritability, mood lability, feelings of brain fog, subtle memory impairment, loss of appetite, sleep disturbances, and gastrointestinal discomfort or dysmotility [10]

Programmed cell death protein 1 (PD-1) is a surface receptor, expressed on highly differentiated effector T cells which act as a negative regulator, and become exhausted and anergic due to chronic antigenic exposure [65]

The symptoms are thought to be mediated by the central nervous system and treatments are aimed at calming down the nervous system thus reducing pain

High feverespecially during the first trimesterhas been associated with adverse outcomes, including neural tube defects and miscarriage