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Institute of Laboratory Animal Resources, National Research Council, National Academy of Sciences

Interestingly, the PKC pathway can also be activated by FSHR via formation of IP3 and DAG and this leads to the expansion of cumulus cells and meiotic maturation of oocytes (123), again neatly demonstrating crosstalk between gonadotropin GPCRs and GH/IGF signaling., The interconnection of these signaling systems at least partly explains the physiological effects observed in vitro / ex vivo

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Mechanistically, -KG insufficiency inhibits TET-dependent transcription of YBX1, an RNA-binding protein required for human-specific AMPK protein synthesis