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10.1038/s41584-024-01110-y 18 KronbichlerA.BajemaI

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Notably, PPAR has also been reported to activate the AMPK-SIRT1 pathway in human articular cartilage, which not only helps to enhance the energy metabolism and antioxidant capacity of chondrocytes, but also further attenuates inflammatory injury and maintains the functional integrity of cartilage tissue 38

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Development Status as of July 2026 Likewise, research programs can change rapidly