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By binding copper(II) ions, it helps regulate gene expression linked to collagen formation, angiogenesis, antioxidant defense, and tissue remodeling. The peptides small size allows it to penetrate tissues efficiently, and its copper-transfer activity underlies its reported effects on skin, hair, and wound-healing processes in laboratory models

Similarly, pre-treatment of IWP2, an inhibitor of Wnt secretion by preventing protein palmitoylation 26 , also reduced the NTAPP-induced -catenin and proteins related downstream signaling (Fig

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