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Because the drug regulates blood sugar levels, reduces appetite, and slows down stomach emptying, one of its side effects is weight loss

In addition, emerging work suggests that specific microbiota-derived secondary bile acids can directly suppress colonic inflammation through epithelial cGMP-PKG signaling (with downstream restraint of mTORC1), providing a mechanistic link between bile acid remodeling and mucosal protection 151

GLP-1's Role in Neuroprotection: a Systematic Review

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For clinicians, understanding and explaining this phenomenon is essential

J Neurochem 87(5):11371144 Rosen DR, Siddique T, Patterson D, Figlewicz DA, Sapp P, Hentati A, Donaldson D, Goto J, ORegan JP, Deng HX, Rahmani Z (1993) Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis