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249 In the brains of transgenic parkin-deficient mice, the inhibition of p53 caused by parkin deficiency increases XBP-1 expression, which in turn promotes DJ-1 expression by binding and transactivating the DJ-1 gene promoter

Twelve highly efficacious drugs with low half-maximal inhibitory concentration values for the treatment of other cancers, which are not yet approved for melanoma treatment, were used for in vitro validation using melanoma cell lines