Buse JB, Wexler DJ, Tsapas A et al (2020) 2019 update to: management of hyperglycemia in type 2 diabetes, 2018
For oral semaglutide, a statistically significant improvement was seen in triglycerides ( 0.69 1.64 mmol/l, p = 0.02), and albumin (+ 1.14 2.44 mmol/l, p = 0.01), (Table 2)
Many patients are challenged by the drugs side effects especially at higher doses
The delayed stomach emptying isn't dangerous, but it can be uncomfortable
However, GI side effects (nausea, vomiting) peak during dose increases, so some patients prefer scheduling lipo C earlier in the week and Zepbound later (e.g., Monday/Friday instead of Monday/Thursday) to separate potential nausea windows further
Mechanism of action at the cellular level GHK-Cu acts via multiple complementary pathways simultaneously