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Senescent cells also play useful roles in wound healing and tumor suppression, so clearing them is not automatically beneficial

Conclusion: A Foundation for Longevity Age management is evolving beyond surface-level treatments toward approaches that address the underlying biology of aging

Xin H, Dziadek S, Bundle DR, Cutler JE

The Na + /K + -ATPase dysfunction and subsequent calcium overload not only impair energy utilization but also further promote mitochondrial ROS production and mtDNA release, which may serve as DAMPs to activate downstream immune pathways, forming a metabolic-immune cross-talk at the cellular level

Zonisamide is an antiepileptic agent with multimodal pharmacodynamics including sodium and calcium channel blocking as well as dopaminergic properties (e.g

Because of this dual role, MOTS-c is often described as a mitokine a mitochondrial-derived signaling molecule that influences cells throughout the body