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Over time, untreated OSA increases the risk of hypertension, heart disease, stroke, type 2 diabetes, and cognitive decline

Majority of patients read, check their phones or just sleep during this period

Common pharmacological triggers include antihistamines, antidopaminergic antiemetics, most antidepressants (particularly selective serotonin reuptake inhibitors and tricyclic antidepressants), and some antipsychotic medications

secondary IR cross-reactivity Key downstream pathways / PI3K-Akt-mTOR and RAS-MAPK-ERK IGF-1 DES comparison / DES is 6-aa truncated, 10x higher potency but even shorter half-life (~20-30 min) Regulatory status / Not FDA-approved for any indication

The development of artificial intelligence facilitates rapid validation of scientific hypotheses in this field, and is also a powerful tool for the development of IC/BPS diagnostic biomarkers

The effects of sleep deprivation and subsequent recovery on the central nervous system