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During the initial treatment period with methylcobalamin, pulmonary edema and congestive heart failure have reportedly occurred early in treatment with parenteral methylcobalamin

Micu et al., 2016, 2018), oxidative stress (Cheignon et al., 2018), mitochondrial impairment (de la Cueva et al., 2022) (well documented in the MS brain

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At this time it is unclear whether free radical involvement in Parkinson's disease is a primary or secondary event in nigral cell death or whether it occurs early or late in the disease process

Accordingly, these markers were found counteracted in CreERT2 mice after LCC challenge

Discussion We have expanded our previous model of one-carbon metabolism to include the transsulfuration pathway, the synthesis and export of glutathione, and its breakdown in and export from the blood