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10.1007/s10695-012-9722-1 16 ChernorudskiyA.VaroneE.ColomboS.FumagalliS.CagnottoA.CattaneoA.et al (2020)

Factors conferring relative protection to children from the toxic effect of paracetamol overdose include increases in paracetamol sulphation capacity [44,45,46,47,48], relative immaturity of the CYP450 oxidation system [15, 46, 49, 51] and the larger relative liver volume found in children [59] but these theoretical mechanisms have not been confirmed