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The structurally diverse, rigid, hydrophobic groups of the different statins are accommodated in a shallow nonpolar groove that is present only when COOH-terminal residues of HMG-CoA reductase are disordered

Hypoxic mice were administered hypoxic treatment in a closed hypoxic chamber (China Innovation Instrument Co., Ltd, Ningbo, Zhejiang, China), which accurately set the desired hypoxic concentration and pattern

In general, there is an age-related increase of 5hmC levels in the brain, pointing towards a role for 5hmc in the development of AD [136, 149, 150]

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