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Targeted brain delivery of methotrexate by glutathione PEGylated liposomes: how can the formulation make a difference

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Our analysis relied on animal experiments, rendering the direct translation of therapeutic mechanistic findings to acupuncture treatment in humans, particularly in patients with TBI, somewhat challenging

IP administration up-regulated oxidative phosphorylation, triggered DNA repair pathways, and activated E2F and p53 signaling networks, acting more like a hormetic stressor or an acute repair trigger