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Concurrently, resistance training directly stimulates the PI3K/Akt/mTOR pathway, promoting muscle protein synthesis and hypertrophy, while also upregulating IRS-1 expression and enhancing insulin sensitivity in muscle (144, 147)

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PMID: 19136019 PMID: 12834882 Reference Reading Foundational Design Paper 1989 Cyclic-lactam -MSH analogs including Melanotan II origin and melanotropic potency Al-Obeidi, Castrucci, Hadley, and Hruby reported the design and synthesis of the 23-membered lactam-bridged cyclic heptapeptide (this compound) and documented 100-fold enhanced melanotropic potency vs -MSH in the lizard skin bioassay