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In a randomized, parallel-group, open-label actively controlled clinical trial that included 91 pregnant women with type 1 diabetes who were administered TRESIBA once daily and insulin aspart, beginning in gestational weeks 8 to 13 or prior to conception, no clear evidence of maternal or fetal risk associated with TRESIBA use was observed (see Data)

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Options include: Returning to the previous dose: If heartburn appeared at 10mg but was absent at 7.5mg, stepping back to 7.5mg for a longer period before attempting escalation again often works

When you add up all sessions, the total investment often surprises patients