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The upregulation of mammalian target of rapamycin (mTOR), a master regulator of translation initiation, results in the increased expression of cancer-promoting genes such as eIF4E, a limiting factor for translation initiation in most cancers, including ovarian cancer [79,80]

The current relatively high frequency of such reports could possibly be due to the fact that there are so many new users of the drug, who are still knee-deep in an expected adjustment period

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Advisable to clarify current magnesium status