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In mouse models of diabetes, Cyp17A inhibition leads to a marked glucose lowering effect (147, 148)
and (4) a combination of Sema with blocking antibodies to GDF8 and ActA (Sema + -MSTN/-ActA)
It is also why elevated IGF-1 raises theoretical concerns about cancer promotion in individuals with pre-existing malignancy or strong genetic risk.8 Any peptide protocol in an adult over 60 must include a pre-treatment cancer screen and should not be initiated in individuals with active or recent cancer history without oncology input
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It is given as a weekly injection.