Guidance such as the ADA/EASD Management of hyperglycaemia in type 2 diabetes consensus report (Davies et al, 2022) recommends early initiation of GLP-1 RAs or SGLT2 inhibitors along with metformin in those with established or high risk of cardiovascular disease, and it is usual practice to titrate one drug up fully before adding the second class, without waiting for further glycaemic assessment
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If youve made meaningful changes to diet, exercise and lifestyle but still arent seeing the weight loss results you need, you may be wondering what the next step should be
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Khavandegar A, Heidarzadeh A, Angoorani P, Hasani-Ranjbar S, Ejtahed H-S, Larijani B, et al
Bergomi M, Rovesti S, Vinceti M, Vivoli R, Caselgrandi E, Vivoli G