glp-1/gip peptide Targeting GLP-1, GIP & GCG in Obesity and Type 2 Diabetes Research GIP and GLP‐1, the two

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They found a peptide in Gila monster saliva, exendin-4, that mimicked human GLP-1 but resisted breakdown

Sun, B., Willard, F.S., Feng, D., Alsina-Fernandez, J., Chen, Q., Vieth, M., Ho, J.D., Showalter, A.D., Stutsman, C., Ding, L., Suter, T.M., Dunbar, J.D., Carpenter, J.W., Mohammed, F.A., Aihara, E., Brown, R.A., Bueno, A.B., Emmerson, P.J., Moyers, J.S., Kobilka, T.S., Coghlan, M.P., Kobilka, B.K., Sloop, K.W

It includes altered liver function, hepatic insulin resistance and lipotoxicity as key features, all of which are influenced by gut alterations that result in increased intestinal permeability [8]

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