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Kim SR, Chen X, Oo TF, Kareva T, Yarygina O, Wang C, et al

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Structurally, the product was optimized on the basis of exenatide, and the glycine 2, methionine 14 and asparagine 28 positions were modified to improve enzyme stability and chemical stability based on the polypeptide backbone

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Researchers believe several mechanisms may contribute to these observations