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The free (unbound) T3 is what can enter and affect the body tissues

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Although some TCM bioactive components have come into preclinical trials, it is essential to initiate preclinical pharmacologic and toxicologic researches to evaluate their efficacy and safety

In patients with hypothalamic obesity, those peripheral signals arrive at a hypothalamus that cannot act on them, because the MC4R pathway downstream of -MSH is silenced

In practical terms, this often pushes people back toward safer, non-pharmacologic options: topical self-tanners (dihydroxyacetone), controlled UV exposure with medical-grade phototherapy when indicated, or simply accepting natural skin tone and focusing on photoprotection

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