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GLP-1 directly activates anorexigenic POMC and CART neurons and indirectly inhibits, via GABAergic transmission, orexigenic NPY and AgRP neurons [39]

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If youre considering GLP-1 therapy or injections, such as semaglutide or liraglutide, its natural to wonder: how long does GLP-1 actually stay in your system

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Phentermine, an FDA-approved appetite suppressant since 1959, works through central nervous system stimulation, while tirzepatide (Zepbound, Mounjaro), approved in 2023 for obesity, operates through dual GIP/GLP-1 receptor pathways