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In vivo metabolic research employs diet-induced obesity mouse models (DIO C57BL/6) or genetic diabetic models (db/db, ob/ob) with controlled sema dosing and comprehensive metabolic phenotyping including indirect calorimetry, glucose and insulin tolerance tests, body composition by NMR or DXA, and tissue-level molecular profiling of liver, fat, and muscle samples

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healthcare programs, imprisonment, contractual damages, reputational harm, diminished profits and future earnings, and curtailment of our operations, any of which could adversely affect our ability to operate our business and our results of operations