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Conclusion Melanosis coli is a benign and reversible condition characterised by the accumulation of pigment-laden macrophages within the colonic mucosa

Its overactivation disrupts nicotinamide metabolism, reduces NAD+ levels, promotes hepatic lipid accumulation and lipotoxicity, and represents an important therapeutic target for hepatic metabolic disorders

At screening (up to 4 weeks prior to baseline), volunteers underwent a review of the inclusion/exclusion criteria, medical history and concomitant therapies, activity levels assessed, had anthropometric and vital sign measures taken, and provided fasting blood samples for safety analysis

So far, clinical trials havent resulted in regulatory approval, and pharmaceutical companies havent been motivated to invest in further development

H., van Rheenen, J., et al

Vitamin B12 injections are only available via a doctors prescription following a clinical diagnosis of low levels