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Application to inappropriate skin areas : Patients may inadvertently apply patches to sites with excessive hair, active skin conditions, or areas prone to friction

N Engl J Med 2021;385:50315.ArticlePubMed 33

doi: 10.1210/clinem/dgaa577

One study with more than 300 participants saw a 15.8% decrease in body weight for semaglutide after 68 weeks.3 Another study saw a 12.4% decrease after 72 weeks.4 Averaging those two outcomes, someone weighing 200 pounds could reasonably expect to lose around 14% of their body weight after about 16 months

Occasionally, and for unknown reasons, a person might be unable to tolerate even a small dose of a GLP-1 agonist, requiring an alternative approach

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