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Patients with certain genotypes may respond optimally at lower doses, while others require higher escalation

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However, when osteoarthritis affects the knee joint, this protective layer is broken down through wear and tear, resulting in pain, swelling and issues with joint movement

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This causes inflammation, which is partly due to bacteria on the skin but also due to activating the immune response due to damaged cells within the dermis.[ref] A blocked hair follicle may bring to mind an ingrown hair from shaving, but instead of just a little inflammation, in HS, the bodys innate and adaptive immune system goes into overdrive