In the phase 3 OASIS 4 trial, adults taking a 25 mg daily dose of oral semaglutide lost an average of 13.6% of their body weight, compared with a placebo
Clinical recommendations to manage gastrointestinal adverse events in patients treated with Glp-1 receptor agonists: a multidisciplinary expert consensus
Compounded semaglutide from the providers on this list costs $149-299/month
Lancet 374(9683):3947 BYDUREON BCISE TM (2017) (exenatide extended-release) injectable suspension, for subcutaneous use [prescribing information]
Across published clinical trial work, researchers have studied it for weight management, weight reduction, body composition, fat loss, appetite suppression, and broader metabolic regulation, with reported doses up to 12mg by subcutaneous injection

Foods to prioritise include: Lean proteins such as chicken, turkey, white fish, and eggs, which are generally well-tolerated and less likely to cause gas Cooked vegetables rather than raw ones, as cooking breaks down fibres that can be harder to digest Low-FODMAP options including carrots, courgettes, spinach, and potatoes, which produce less fermentation (note: low-FODMAP diets should be trialled short-term and ideally supervised by a registered dietitian) Smaller, more frequent meals rather than three large meals, reducing the burden on your slowed digestive system (if you also use insulin or sulfonylureas, monitor for hypoglycaemia when changing meal patterns and seek advice from your diabetes team) Adequate hydration with still water throughout the day, avoiding carbonated beverages that introduce additional gas Foods and habits to limit or avoid: High-fat meals , which take considerably longer to digest and can exacerbate feelings of fullness Cruciferous vegetables (broccoli, cauliflower, Brussels sprouts, cabbage) and legumes (beans, lentils), which are notorious gas producers Artificial sweeteners such as sorbitol and xylitol, commonly found in sugar-free products, which can cause bloating and diarrhoea Carbonated drinks , including sparkling water, which directly introduce gas into the digestive system Eating too quickly , which causes you to swallow excess air Keeping a food diary for several weeks can help identify specific triggers unique to your digestive system
