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The study on polymorphisms of sep15 and TrxR2 and the expression of AP-1 signaling pathway in Kashin-Beck disease

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It is activated through ligand-induced proteolytic cleavage of NOTCH receptors, leading to the release and nuclear translocation of the NOTCH intracellular domain, which subsequently forms a transcriptional complex that regulates downstream gene expression

10.1016/j.lfs.2018.03.036 256 ZhangH

And maybe here is a good place to spell out just how long the development and approval process for these drugs can be