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It can cause: Mild, pounding headaches Fatigue Reduced concentration Mild dizziness You may notice these more during hot weather, exercising, or if you are sweating a lot

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Treatment is rarely undertaken, because disease is often advanced at the time of diagnosis, and many patients have complications such as aspiration pneumonia

You may notice changes in pronunciation or experience embarrassing slippage while talking

We found a good correlation between the in vitro and in vivo drug brain permeability (R 2 = 0.83