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For example, while almost all assays rely on ApoC-II mediated activation of LPL, the source of ApoC-II can range from serum samples taken from individuals or a pool of healthy individuals (46, 55, 56, 64), VLDL (65), ApoC-II protein (66), or ApoC-II peptide (27)

The pattern typically looks like this: diarrhea appears or worsens within first few days after a dose increase, lasts for several days to a couple of weeks, and then settles as body adjusts

Although advertisements and promotional materials suggested that the drugs carry few serious side effects, former users claim that the manufacturers withheld critical safety information and warnings to increase profits from the drugs

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Both undermethylation and overmethylation are problematic

10.1016/j.plefa.2009.06.003