Human studies show that I3C pushes more estrogen toward the favorable 2-hydroxyestrone route (the less active one) and reduces the amount going down the more estrogenically active 16-hydroxyestrone pathway [7, 8]
But as evidence propositions they are worlds apart: one is an FDA-approved drug with replicated Phase 3 trials, the other is an unapproved research chemical with two small surrogate-marker studies and discontinued development
Side Effects Adverse effects resulting from this supplement alone are uncommon, but may include: Gastric effects Headaches Kidney damage Kidney damage is very rare and is usually only a risk if your dog has pre-existing renal problems, or if massive overdose amounts are ingested
ECL1 forms two hydrogen bonds with Q23 P (via W214 ECL1 ) and E27 P (via Q211 ECL1 ), as well as stacking interaction with F28 P (via W214 ECL1 )
Multiple studies confirm enhanced penetration when combining microneedling with topical glutathione
If you feel you need a more powerful tool, its higher efficacy is a major talking point
