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As a cofactor for nitric oxide synthase (NOS), BH4 inhibits NOS overactivation, thereby mitigating oxidative stress ( 4 /BH 2 (dihydrobiopterin) inhibit ferroptosis via lipid remodeling, specifically by selectively protecting phospholipids containing two polyunsaturated fatty acyl chains and enhancing the reduced state of CoQ 10 ( 3 Ferroptosis and ophthalmic diseases 3.1 Advances in ferroptosis and related ocular diseases In previous studies (Figure 2), experts mostly associated ferroptosis with tumors

Environmental Factor UV rays, Pollution, stress, etc increase free radicals 2