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This PUFA membrane enrichment is triggered by the specific enzyme acyl-CoA synthetase long-chain family member 4 (ACSL4)

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Figure 2: Glutamate is derived from glutamic acid from digested proteins, free glutamic acid, and glutamate salts such as MSG and MPG

43 Several studies reported that Nrf2 and its transcriptional activity decline with increasing COPD severity 44-46 allowing for the hypothesis that sulforaphane may decrease oxidative stress and inflammation in COPD patients