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An imbalance of the gut microbiota can lead to immune activation and inflammation, particularly through an increase in pro-inflammatory lipopolysaccharides (LPS), which results in increased production of inflammatory cytokines, such as TNF-, IL-1, and IL-6 (218)

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C., Campbell, K., & Suresh, C

Morales DK, Grahl N, Okegbe C, Dietrich LE, Jacobs NJ, Hogan DA

Beyond angiogenesis, BPC-157 also modulates the nitric oxide system (which plays a role in tissue protection), increases FAK-paxillin expression (involved in cell adhesion and growth), and has been shown in animal studies to reduce inflammatory cytokines

A final issue with respect to collagen V mutations and classical EDS is the question of what fraction of patients actually carry mutations in the COL5A1 or COL5A2 genes