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For decades, the answer to can oral glutathione supplementation work? was a clear no

The reaction is catalyzed by a family of enzymes called Glutathione S-transferases (GSTs), which facilitate a nucleophilic attack, covalently binding the sulfur atom of glutathione directly to the toxic Phase I metabolite

After two weeks of tolerance, you can increase frequency to daily use

doi: 10.4161/psb.6.4.13912 68 SatohK.KondohH.De LeonT

A study found that vitamin C supplementation (500-1,000 mg/day) increased lymphocyte glutathione by 18% (Lenton et al., Am J Clin Nutr, 2003) [24]