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10.1016/j.cca.2019.02.022 34 OsburnW.WakabayashiN.MisraV.NillesT.BiswalS.TrushM.et al (2006)

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Intestinal immune cell-derived overactivation of NOX and inducible nitric oxide synthase (iNOS) generates excessive ROS, which oxidatively damage tight junction proteins in epithelial cells, compromising intestinal barrier integrity

Clinical Data Support: Presence of clinical trial reports demonstrating improvements in skin brightness and reduction in melanin density

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