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A cohort study of moderate and severe head injury patients found that 67% of the cerebrolysin group achieved good outcomes (GOS 3-5) at 6 months, compared favorably to historical controls matched for age, sex, and initial severity

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That is, a reasonable target at one time point during development may be inappropriate at another time point because of structural and functional changes based on neuronal migration, circuit connectivity, synaptic plasticity, and gene expression

Bernetti, M