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To increase affinity toward CD36, researchers modified the linker region of the VHL-based PROTAC MZ1 by introducing cleavable polar groups (e.g., carboxyl, amino, Boc-protected groups)

Effects of Semaglutide on Adipose Tissue Biology in Type 2 Diabetes 4.1

Using single-cell RNA-seq expression data specifically from stage 6 SC-islet cells, we first identified a developmental trajectory from immature INS + cells co-expressing the key endocrine progenitor transcription factor FEV to more mature cells with higher INS expression and low/absent expression of FEV (Supplementary Fig

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